Omeprazole Side Effects (Prilosec)

How Does Zegerid Function In Me?

Zegerid is a combination of Omeprazole (proton pump inhibitor) and sodium carbonate (an antacid). Omeprazole is the most commonly used proton pump inhibitor that inhibits gastric acid secretion.

Mechanism of action

The parietal cells of the stomach secrete H+ with the help of H+K+ ATPase enzyme present in the plasma membrane and this is the final step in gastric acid secretion due to all stimuli. Proton pump inhibitors accumulate in the parietal cells where they specifically and irreversibly inhibit H+K+ ATPase and thereby inhibit gastric secretion. Omeprazole gets activated in the acidic environment of the stomach to sulfenamide which binds covalentely with H+K+ ATPase. The binding is irreversible. A single dose almost inhibit gastric secretion.

Adverse effects

Omeprazole is well-tolerated. Prolonged acid suppresion may allow bacterial over growth in the stomach. Dizzinesss, headache, diarrhoea, abdominal pain, nausea, arthralgia and rashes may occur. Long term administration result in vitamin B12 defficiency due to its absorbed absorption, decreased rastrin levels, atrophic changes in the stomach noticed after 3-4 years of use.

Uses of PP Inhibitors

Used in GERD that does not respond to H2 blockers. They also form a component in Helicobacter pylori treatment regimen. PP Inhibitors are also used in Zollinger Ellison Syndrome assosciated with gastrin secreting tumors.

Sodium Carbonate, an antacid is rapid but short-acting. it nueutralize the gastric acid and raise the pH of gastric contents.

GERD (Gastroesophageal Reflux Disease) - reflux of gastric acid contents into the oesophagus results in 'heart burn' dut to oesophagitis. Chronic oesophagitis result in changes in the oesophageal mucosa which could be a premalignant condition. Based on severity, GERD is treated with antacids ,H2 receptor blockers. In moderate to severe cases, proton pump inhibitors like omeprazole are the drugs of choice.

Zegerid is used in adults:

• For 4 weeks to heal ulcers in the first part of the small bowel (duodenal ulcers).
• For up to 8 weeks for healing stomach ulcers
• For up to 4 weeks to treat heartburn and other symptoms that happen with gastroesophageal reflux disease (GERD).

Before taking Zegerid, tell doctor if you:

• Have low magnesium levels in your blood, any liver problems, heart failure, Bartter syndrome (a rare kidney disorder)
• Suffer from any allergies
• Are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed. Sodium bicarbonate (a part of ZEGERID) should be used with caution in nursing mothers.

Tell doctor about all the medicines you take including vitamin and herbal supplements.

Zegerid should be taken exactly as prescribed by the doctor. Do not change dose or stop taking Zegerid without talking to doctor. Take it for as long as it is prescribed - even if you start feeling better! For best effect, take Zegerid on an empty stomach at least one hour before a meal.

How to take Zegerid

Empty the contents of a packet of Zegerid Powder for Oral Suspension into a small cup containing 1-2 tablespoons of water. Stir well and drink immediately. Refill cup with water and drink. Donot use other liquids or fluids. Do not open the capsule and sprinkle contents into food. Do not take two doses to make up for a missed dose.

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